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Is It Neuropathy or Peripheral Artery Disease?


You used to get up every morning to walk around the entire neighborhood. Now, you can barely get up to walk down the stairs. This cramping, burning sensation in your legs has just gotten worse over time, but you’re not sure what it could be.

Painful symptoms such as tingling and numbness in your legs and feet especially when you have diabetes can indicate peripheral neuropathy or peripheral artery disease. If you are experiencing any of these feelings, we suggest you consult your doctor to discuss the possibility of these two progressive disorders.


What Is Peripheral Neuropathy?

Woman experiencing peripheral neuropathy symptoms

Peripheral neuropathy, also known as peripheral neuritis, occurs when the nervous system becomes damaged or diseased. There are a few different causes of peripheral neuropathy; however, one of the most common is diabetes. Ignoring high blood sugar levels (hyperglycemia) over time can contribute to peripheral neuropathy. Increased amounts of blood sugar can damage nerves and interfere with their ability to send signals to the rest of the body.

Additionally, hyperglycemia can weaken the walls of your blood vessels. When your blood vessels are not able to deliver oxygen and nutrients to your essential organs, your peripheral neuropathy symptoms will worsen.

Can Peripheral Neuropathy Cause Leg Pain?

let pain


One of the most common peripheral neuropathy symptoms is pain in the legs or feet. Neuropathy pain in the feet may start as a tingly feeling but can soon become severe causing complete numbness. People with peripheral neuropathy symptoms may only have them in one or both feet. Many patients report an increase in neuropathy pain in their feet during the night, which disrupts their sleep.

Depending on your level of activity during the day and the severity of your condition, the pain may feel stabbing or more intermittent. Neuropathy pain in your feet or legs may cause you to avoid certain activities like walking and climbing stairs. If not addressed timely, diabetic neuropathy may develop into complete numbness and atrophy making you immobile. It’s important to talk to your doctor to see what exercises and stretches could help alleviate your discomfort.

Additional Peripheral Neuropathy Symptoms

Woman laying in bed with diabetic leg pain

Not only do peripheral neuropathy symptoms make walking painful and difficult, but it can cause additional symptoms such as:

  • Burning sensations
  • Cramping or general achiness
  • Lack of feeling, tingly, or numbness in the legs/feet
  • Reduced coordination or balance
  • Difficulty sleeping due to leg or foot pain

Due to the fact that it is considered to be a progressive disorder, peripheral neuropathy symptoms may affect your lower extremities at first but then include your upper extremities, like your hands or feet, later on.

How Bad Can Peripheral Neuropathy Get?

Foot with small open wound

Peripheral neuropathy can easily be treated, especially if it is diagnosed early. However, it’s important to note that it is a progressive condition that will worsen over time. Peripheral neuropathy symptoms can become quite severe affecting your quality of life and reducing mobility.

Additionally, due to the lack of feeling in your legs or feet, you may miss signs of an infection including small wounds. This can become quite serious, resulting in amputation, if not treated accordingly. If you notice slow or non-healing wounds on your foot, it’s crucial to note that peripheral neuropathy is not the only cause. Vascular diseases like peripheral artery disease (PAD) can also cause open wounds to not fully heal, leading to serious infection. Furthermore, nerve damage from diabetes can affect the functions of internal organs such as the digestive tract, heart, kidneys, and sexual organs.


The Difference Between Peripheral Artery Disease and Peripheral Neuropathy

stages of plaque buildup within the arteries

Peripheral artery disease (PAD), also referred to as peripheral vascular disease, is caused by plaque buildup within the arteries. When arteries become clogged, crucial oxygen and nutrients aren’t able to reach the lower extremities. Consequently, people with PAD may experience painful symptoms in their legs and feet.

The major difference between peripheral neuropathy and peripheral vascular disease is that PAD affects the arteries and neuropathy affects the nervous system. Because both conditions have similar symptoms, it’s important to consult your doctor as soon as possible. Peripheral neuropathy and peripheral vascular disease can be challenging to self-diagnose because leg pain or other symptoms are often difficult to track or explain. Make sure to write down what you’re experiencing daily to accurately inform your specialist.

To consult an experienced vascular specialist about your pain or symptoms, call 888.773.2193 or click here to schedule an appointment online.

What Do Peripheral Artery Disease Symptoms Feel Like?



Because peripheral artery disease affects the lower extremities, they can sometimes be mistaken for peripheral neuropathy symptoms, and vice versa. However, in contrast, there are a few outlying symptoms that set them apart; they include:

  • Cramps in the thigh, calf, ankle, buttocks, or foot
  • Difficulty climbing stairs
  • Fatigue in the legs or achiness
  • Slow or non-healing wounds on the leg, ankle, or foot
  • The temperature of one leg is cooler than the other
  • Leg hair loss or poor toenail growth
  • Numbness or weakness in the legs
  • Pain that stops at rest
  • Paleness or blueness in one or both legs

Unfortunately, diagnosing PAD isn’t always easy. Depending on the individual’s case and severity, some patients experience little to no symptoms. If you’re at risk, are experiencing symptoms, or have a family history of PAD, get checked. Just like peripheral neuropathy, it’s important to catch PAD before it worsens.

Peripheral Neuropathy and Peripheral Vascular Disease

Doctor examining mans leg with pad

The common denominator of peripheral neuropathy and peripheral vascular disease is diabetes. Where peripheral neuropathy may weaken your arterial walls, peripheral artery disease makes them rough allowing plaque to accumulate. If you think your diabetic leg pain is caused by either of these conditions, discuss it with your doctor and get tested. People with diabetes should communicate regularly with their doctor, work to lower their blood sugar, as well as actively decrease their blood pressure and cholesterol levels.

Peripheral neuropathy and peripheral vascular disease can both affect your quality of life by decreasing your mobility. Living a sedentary life can cause both conditions to progress at an increased rate. Receiving a PAD or peripheral neuropathy diagnosis can help determine the treatment path your doctor will take.

PAD vs. Peripheral Neuropathy Diagnosis

Doctor examining mens legs on clinic table

As you can see, both peripheral neuropathy and peripheral vascular disease can be easily mistaken for one another. It’s important to receive a clear PAD or peripheral neuropathy diagnosis to proceed. Thankfully, both of these conditions can be treated easily.

If you’re living with PAD or neuropathy and walking has become difficult, it’s a good idea to get tested. Whether you have diabetes or not, you should get tested if you’re exhibiting symptoms. At USA Vascular Centers, we diagnose and treat peripheral artery disease through nonsurgical, outpatient methods. If you’re not sure if vascular disease or neuropathy is behind your leg pain, our specialist can help. Give us a call at 888.773.2193 or contact us online to schedule an initial consultation.

Don’t want to leave your house to consult with one of our vascular specialists? No problem! We are offering convenient, virtual, telemedicine appointments.

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